Publications

2018

Sharpe HJ and de Sauvage FJ (2018) Grking the Smoothened signal. Sci. Signal.

2016

Sharpe HJ (2016) A new trick for an old lipid. [Insight commentary] eLife.

Bonilla X, Parmentier L, King B, Bezrukov F, Kaya G, Zoete V, Seplyarskiy VB, Sharpe HJ et al. (2016) Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma. Nat. Genet. 8:398-406

2015

Sharpe HJ, Wang W, Hannoush RN, de Sauvage FJ. (2015) Regulation of the Smoothened oncoprotein by small molecules. [Review] Nat. Chem. Biol. 11:246

Sharpe HJ, Pau G, Dijkgraaf GJ, Basset-Seguin N, Modrusan Z et al. (2015) Genomic analysis of Smoothened inhibitor resistance in basal cell carcinoma. Cancer Cell. 27:327

Basset-Seguin N, Sharpe HJ, de Sauvage FJ. (2015) Efficacy of Hedgehog pathway inhibitors in basal cell carcinoma. [Review]  Mol. Cancer Ther. Epub ahead of print

2012

Herzig Y*, Sharpe HJ*, Elbaz Y, Munro S, Schuldiner M. (2012) A systematic approach to pair secretory cargo receptors with their cargo suggests a mechanism for cargo selection by erv14. PLoS Biol. 10:e1001329 (*Equal contribution)

Sharpe HJ and de Sauvage FJ. (2012) Signaling: An oxysterol ligand for Smoothened. [News and Views] Nat. Chem. Biol. 18:139

2010

Sharpe HJ, Stevens TJ, Munro S. (2010) Organelle-specific constraints on the composition of transmembrane domains. Cell. 142:158

2009

Strisovsky K, Sharpe HJ, Freeman M. (2009) Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates. Mol. Cell. 36:1048  

2007

Foley DA, Sharpe HJ, Otte S. (2007) Membrane topology of the endoplasmic reticulum to Golgi transport factor Erv29p. Mol. Membr. Biol. 24:259

2006

Colton CA, Mott RT, Sharpe H, Xu Q, Van Nostrand WE, Vitek MP. (2006) Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD. J. Neuroinflammation. 3:27